The Intravascular Contrast Media
Development of Radiographic Agents
![contrast media contrast media](https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiH-6qM4KKIWttgEsYtKYxDc7kt2wiK1aNNyJr9mILRJMFifywaZklgqKcADh4GQZndcn_-_TnT4wuBovMT3NQR6m7ivhDXycMnLVYCDTpki9NGpFzB6iQrBS8z03sQj3_OmlAlDjZUrcjF/s200/contrast+medicine.gif)
In the year 1923, the first reported of an opacification it means "visible radiographically" of the urinary bladder with the use contrast media via intravenous injections. The contrast media used is a 10% sodium iodide solution which is used at this time for treatment of syphilis and excreted with urine. In 1928 a German reseachers synthesized a compound with a number of pyridine rings containing iodine to detoxify the iodine. The first tri-iodinated contrast media was developed the UROKON a sodium acetrizoate in 1952 this compound is from a mono-iodinated compound (pryridine) and developed further into di-iodinated compound and subsequently resulted in tri-iodinated contrast (Urokon). Sodium acetrizoate was based on a six carbon ring structure, tri-iodo benzoic acid, and was the precursor of all modern water soluble contrast media.
Gallbladder, Biliary Ducts, Urinary Tract Oral Contrast
Two-Iodinated Compounds
Gallbadder Oral Contrast Media
1924 -1925 - Tetrabromophenolphthalein Sodium
Tetraiodophenolphthalein
1940 - Priodax
1944 - Monophen
Three-Iodinated Compounds
Gallbladder and Ducts Oral Contrast Media:
1949 - Iopanoic Acid (Telepaque)
1952 - Teledax
1960 - Biloptin
Ipodate Calcium or Sodium (Oragrafin)
1962 - Bilopaque
Six-Iodinated Compounds
Gallbladder and Ducts Oral Contrast Agents:
1952 – 1953 - Biligrafin forte
Cholografin
Gallbladder, Ducts and Urinary Tract Contrast Agents
1956 - Duografin (Cholografin Methylglucamine plus Renografin)
MRI Enhancement Agents