Radiographic Contrast Medium

The Intravascular  Contrast Media

Development of Radiographic Agents

In the year 1923, the first reported of an opacification it means "visible radiographically" of the urinary bladder with the use contrast media via intravenous injections. The contrast media used is a 10% sodium iodide solution which is used at this time for treatment of syphilis and excreted with urine. In 1928 a German reseachers synthesized a compound with a number of pyridine rings containing iodine to detoxify the iodine. The first tri-iodinated contrast media was developed the UROKON a sodium acetrizoate in 1952 this compound is from a mono-iodinated compound (pryridine) and developed further into di-iodinated compound and subsequently resulted in tri-iodinated contrast (Urokon). Sodium acetrizoate was based on a six carbon ring structure, tri-iodo benzoic acid, and was the precursor of all modern water soluble contrast media.

Gallbladder, Biliary Ducts, Urinary Tract Oral Contrast

Two-Iodinated Compounds
Gallbadder Oral Contrast Media

1924 -1925 - Tetrabromophenolphthalein Sodium

Tetraiodophenolphthalein

1940 - Priodax
1944 - Monophen

Three-Iodinated Compounds
Gallbladder and Ducts Oral Contrast Media:

1949 - Iopanoic Acid (Telepaque)
1952 - Teledax
1960 - Biloptin

Ipodate Calcium or Sodium (Oragrafin)
1962 - Bilopaque

Six-Iodinated Compounds
Gallbladder and Ducts Oral Contrast Agents:

1952 – 1953 - Biligrafin forte

Cholografin
Gallbladder, Ducts and Urinary Tract Contrast Agents

1956 - Duografin (Cholografin Methylglucamine plus Renografin)

MRI Enhancement Agents